Agenesis of the Corpus Callosum |Pregnancy Terms | Pregnancy Glossary

A birth defect in which there is partial or complete absence of the corpus callosum (the bundle of nerve fibers that connects the two hemispheres of the brain). ACC may occur as an isolated defect, but it is frequently associated with other malformations, chromosomal abnormalities (trisomy 18 an trisomy 8), and genetic syndromes. The outcome of the abnormality depends on the underlying cause and the presence of other structural defects. Isolated ACC (in particular partial ACC) is associated with no or mild neurologic impairment in a large proportion of cases. ACC occurring as part of a syndrome may be associated with severe mental retardation and seizures. ACC does not cause death in the majority of children. Ultrasound findings include absence of the corpus callosum and cavum septum pellucidum, 'teardrop' configuration of the lateral ventricles, dilatation and upward displacement of the third ventricle (interhemispheric "cyst") , and abnormal branching of the anterior cerebral artery. Magnetic resonance imaging is sometimes useful in confirming the diagnosis. Additional abnormalities commonly found in association with ACC include Chiari malformations, schizencephaly, encephaloceles, Dandy-Walker malformations, holoprosencephaly, heart defects, and GI or genitourinary malformations. The risk of recurrence is ~ 1% for sporadic cases, 25% if ACC is associated with an autosomal recessive cause, and 50% of males will be affected if inherited as an X-linked recessive disorder

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<--Pregnancy Term Keywords --> Pregnancy Abdomen,The Belly,Abdominal circumference (AC),Abortion,Abruptio placenta (Placental abruption),Acceleration,Acromelia,Active Labor,Acute Cervical Insufficiency,Afterbirth,Agenesis of the corpus callosum (ACC),Akinesia,Alloimmunization (Isoimmunization),Alpha-fetoprotein (AFP),Amniocentesis,Amnioinfusion,Amniotic fluid,Amniotic Fluid Index (AFI),Amniotic fluid ‘sludge’,Amniotic sac,Amniotic sheet,Amniotomy (artificial rupture of membranes , AROM),pregnancy terms,

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,Anemia,Anencephaly,Anesthesia,Angle of insonation,Anomaly,Antenatal,Antenatal corticosteroids , ACS,Antepartum,Anterior,Antibody (Immunoglobulin),Anticardiolipin antibodies (ACA, aCL Antibody) *,Anti-c antibody (little c antibody) *,Anti-D antibody (Rh sensitization, Rh disease)*,Anti-Duffy antibody (anti-Fya antibody),Anti-Kell antibody,Anti-Kidd antibody (anti-Jka or anti-Jkb),Anti-Lewis antibody,Anti-S antibody,Apgar Score